Maribavir isomers, compositions, methods of making and methods of using
AssigneeShire ViroPharma Incorporated
InventorJohn D. Peabody, III
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Abstract
The invention relates to novel compositions and methods of using maribavir which enhance its effectiveness in medical therapy, as well as to maribavir isomers and methods of use thereof for counteracting the potentially adverse effects of maribavir isomerization in vivo in the event it occurs.
Claims9
A composition comprising maribavir and at least one of an antacid which is effective for neutralizing acid that catalyzes isomerization of maribavir, (ii) an antibiotic having activity against a microorganism that mediates isomerization of maribavir, or (iii) an antagonist that inhibits metabolism that induces isomerization of maribavir, said isomerization producing a decrease in the therapeutic efficacy of maribavir.
Dependencies are inferred from the claim text.