TLR4 agonists and compositions thereof and their use in the treatment of cancer
AssigneeGlaxoSmithKline Intellectual Property Development Limited
InventorsChristopher W. Cluff, Hua-Xin Gao
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Abstract
Disclosed is a TLR4 agonist alone or in combination with an anti-cancer agent and pharmaceutical compositions thereof, uses thereof, and methods of treatment comprising administering said composition or combination, including uses in cancer.
Claims9
A method of treating cancer in a human in need thereof comprising administering a composition comprising a TLR4 agonist which is CRX-601, having the formula shown below:
- for treating cancer and combined with an anti-cancer agent, wherein the cancer is a solid tumor and selected from the group consisting of (1) primary and secondary metastatic forms of head and neck cancer and (2) carcinoma of the head and neck.
A method of treating cancer in a human in need thereof comprising administering a pharmaceutical composition comprising a therapeutically effective amount of an anti-cancer agent and a second pharmaceutical composition comprising a therapeutically effective amount of the TLR4 agonist, which CRX-601, having the formula shown below:
- wherein the cancer is wherein the cancer is a solid tumor and selected from the group consisting of (1) primary and secondary metastatic forms of head and neck cancer and (2) carcinoma of the head and neck.
Dependencies are inferred from the claim text.