Apilimod for use in the treatment of melanoma
AssigneeAI Therapeutics, Inc.
InventorsNeil Beeharry, Sophia Gayle, Sean Landrette, Paul Beckett, Chris Conrad, Tian Xu, Jonathan M. Rothberg, Henri Lichenstein
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Abstract
The present invention relates to methods for treating melanoma with apilimod and related compositions and methods.
Claims11
A method for treating melanoma in a subject in need thereof, the method comprising administering to the subject a pharmaceutical composition comprising a therapeutically effective amount of apilimod, or a pharmaceutically acceptable salt thereof, and vemurafenib in a single dosage form with the apilimod, or in a separate dosage form.
A method for treating melanoma in a human subject in need thereof, the method comprising assaying a biological sample of the subject's cancer for one or more mutations in the BRAF protein selected from V600E BRAF and V600K BRAF, or the genetic equivalents thereof, identifying the subject having either of these mutations as a patient for treatment with a combination therapy comprising apilimod and vemurafenib, and administering a combination therapy comprising apilimod and vemurafenib to the subject.
A method for treating melanoma in a human subject in need thereof, the method comprising administering to the subject apilimod, or a pharmaceutically acceptable salt thereof, and vemurafenib.
Dependencies are inferred from the claim text.