Polymorphs of ARRY-380, a selective HER2 inhibitor and pharmaceutical compositions containing them
AssigneeArray BioPharma Inc.
InventorsDonald T. Corson, Christopher M. Lindemann, Daniel J. Watson
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Abstract
Polymorphs of N4-(4-([1,2,4]triazolo[1,5-a]pyridin-7-yloxy)-3-methylphenyl)-N6-(4,4-dimethyl-4,5-dihydrooxazol-2-yl)quinazoline-4,6-diamine are provided herein. Processes for preparing the polymorphs and pharmaceutical composition comprising the polymorphs are also disclosed.
Claims19
A method of treating cancer in a mammal in need thereof comprising administering a therapeutically effective amount of a crystalline polymorph of N4-(4-([1,2,4]triazolo[1,5-a]pyridin-7-yloxy)-3-methylphenyl)-N6-(4,4-dimethyl-4,5-dihydrooxazol-2-yl)quinazoline-4,6-diamine to the mammal, wherein the polymorph is selected from the group consisting of Form A, Form B, Form C, Form D, Form E, Form F, Form G, Form H, Form I, Form J, Form K, Form L, Form M, Form N, Form O and Form P, and wherein the cancer is ErbB2 positive colorectal, gastric or esophageal cancer.
Dependencies are inferred from the claim text.