Compositions and methods for treating Ewing family tumors
AssigneeThe Methodist Hospital
InventorsHong Zhao, Stephen T. C. Wong
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Abstract
A method for treating a sarcoma by administering a tyrosine kinase inhibitor and a biguanide compound. Also described is a method for treating a tumor of the Ewing Sarcoma family by obtaining a tumor sample; determining in the sample gene expression levels of ACTB, B2M, MLH1, PRKDC, XPC, APEX1, ERCC5, MMS19, or RAD23; and administering a tyrosine kinase inhibitor and a biguanide compound. Furthermore, a pharmaceutical composition for treating a Ewing family tumor is disclosed. The composition contains a tyrosine kinase inhibitor, a biguanide compound, and a pharmaceutically acceptable excipient.
Claims8
A method for treating a sarcoma, the method comprising administering to a subject having a sarcoma an effective amount of imatinib and metformin.
A method for treating a Ewing family tumor, the method comprising:
- obtaining a tissue sample from a Ewing family tumor in a subject;
- determining in the sample a level of expression of a gene selected from ACTB, B2M, MLH1, PRKDC, XPC, APEX1, ERCC5, MMS19, and RAD23A;
- and
- administering to the subject an effective amount of imatinib and metformin if the level of expression of the gene is elevated as compared to a predetermined level of expression of the gene.
Dependencies are inferred from the claim text.