Composition comprising combination of rapamycin and an activator of AMP kinase and use thereof for treating diseases
OwnerJeffrey M. Melininventor
Life of this patent
Estimating the term…
Abstract
A formulation, especially one that is topically administered, comprising a combination of rapamcycin and metformin in a molar ratio of about 20:1, 10:1, 5:1, 4:1, 3:1, or 1:1. The topical formulation may be a gel, an ointment, a cream or a lotion. The topical formulation may be used to treat any disease associated with inflammation and/or any inflammatory skin disease.
Claims14
A method for treating symptoms of inflammatory arthritis in a subject, wherein the method comprises locally administering an effective amount of a topical formulation directly over an inflamed joint affected by inflammatory arthritis, the topical formulation comprising a combination of rapamycin and metformin, wherein the molar ratio of rapamycin to metformin is in the range of about 20:1 to about 1:1, and wherein metformin acts as an adjuvant to enhance efficacy of rapamycin in the topical formulation.
A method for treating the symptoms of inflammatory arthritis in a subject comprising administering an effective amount of a formulation comprising a combination of rapamycin and metformin to a subject with inflammatory arthritis, wherein the molar ratio of rapamycin to metformin is in the range of about 20:1 to about 1:1.
Dependencies are inferred from the claim text.