Oral compositions delivering therapeutically effective amounts of cannabinoids

A method of treating a disease or disorder associated with abnormal or increased mitogen-activated protein (MAP) kinase activity or levels in a subject, comprising:

• administering to a subject in need thereof, a gum-based composition for chewing, the composition consisting of:
• about 0.1% to about 20% by weight hemp oil extract,
• about 35% to about 80% by weight of a sugar alcohol, or a blend of sugar alcohols,
• about 1% to about 20% by weight of flavoring,
• about 0.1% to about 10% by weight of tableting lubricants and powder flow agents,
• about 0.01% to about 2% by weight of intensive sweeteners, and
• about 5% to about 25% of a gum base,
• based on the total weight of the composition,
• wherein the disease or disorder associated with abnormal or increased mitogen-activated protein (MAP) kinase activity or levels in the subject is selected from the group consisting of a neuroinflammatory disease or disorder, migraines, epilepsy, neuropathic pain, general pain, joint pain, head trauma, or combinations thereof.