US 10,765,655 B2 · Composition containing monoacetyldiglyceride compound as active ingredient for preventing or treating chronic obstructive pulmonary disease

Composition containing monoacetyldiglyceride compound as active ingredient for preventing or treating chronic obstructive pulmonary disease

AssigneesEnzychem Lifesciences Corporation, Korea Research Institute of Bioscience and Biotechnology

InventorsSei-Ryang Oh, Kyung Seop Ahn, Su Ui Lee, In Sik Shin, Ok-Kyoung Kwon, Seung Hyung Kim, Chan Mi Chun, Tae-Suk Lee, Yong-Hae Han, Ki Young Sohn, JongKoo Kang, Hye Kyung Kim

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Abstract

The present invention relates to a pharmaceutical composition containing a monoacetyldiacylglycerol compound as an active ingredient for preventing or treating chronic obstructive pulmonary diseases, and a functional health food composition for treating or preventing chronic obstructive pulmonary diseases. The monoacetyldiacylglycerol compound of the present invention inhibits the IL-4 expression in EL-4 cells and inhibits the infiltration of inflammatory cells into the bronchial tube in an animal model. In addition, the compounds of the present invention have an excellent effect of inhibiting the expression of CXCL-1, TNF-α, or MIP-2, thereby overcoming side effects of the currently used therapeutic agents for chronic obstructive pulmonary diseases, having no toxicity, and exhibiting a superior therapeutic effect, and thus can be useful as a composition for preventing, treating, and alleviating chronic obstructive pulmonary diseases.

Claims5

Dependent claims

A method of treating a chronic obstructive pulmonary disease in a patient, comprising administering to a patient in need of such treatment a pharmaceutically acceptable composition comprising an effective amount of a purified compound of Formula 2:

Dependencies are inferred from the claim text.

Facts

Application

15/857,933Filed 29 Dec 2017 · division

Priority

KR 10-2013-009818419 Aug 2013

Published

US 2018/0280336 A14 Oct 2018

Granted

8 Sep 2020

Term ends

Not estimatedThe source records don’t support an estimate.

Classification7 codes

A61K 31/231
Of acids having a carboxyl group bound to a chain of seven or more carbon atoms: having one or two double bonds
A61P 11/00
Drugs for disorders of the respiratory system
A61P 11/06
Drugs for disorders of the respiratory system: antiasthmatics
A61P 29/00
Non-central analgesic, antipyretic or antiinflammatory agents

Family

PCT/KR2014/007661Parent of this division · filed 19 Aug 2014

US 2018/0280336 A1Pre-grant publication · published 4 Oct 2018

Application14/912,765Parent of this division

US 2017/0042854 A1Published application

US 10,765,655 B2This patent

From the US filing history. Foreign family members aren’t listed.