Reversible nitroxide derivatives of nitroalkenes that mediate nitrosating and alkylating reactions
AssigneeUniversity of Pittsburgh—Of the Commonwealth System of Higher Education
InventorsMarco Fazzari, Bruce A. Freeman, Francisco Jose Schopfer
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Abstract
Various embodiments of this invention are directed to pharmaceutical compositions and methods for treating disease. The compositions of such embodiments include reversible nitroxide derivatives of nitroalkenes. The methods of various embodiments include administering an effective amount of any of these pharmaceutical compositions to a patient in need of treatment.
Claims39
A composition comprising an effective amount of a fatty acid having a formula:
- wherein X1 is H, n is from 1 to 10 and m is from 1 to 10;
- and
- a pharmaceutically acceptable excipient.
A method of delivering nitric oxide comprising administering to a subject in need thereof an effective amount of a fatty acid having a formula:
- wherein X1 is H, n is from 1 to 10 and m is from 1 to 10;
- and
- a pharmaceutically acceptable excipient.
A method of treating inflammation, obesity, metabolic syndrome, acute kidney disease, or chronic kidney disease comprising administering to a subject in need thereof an effective amount of a fatty acid having a formula:
- wherein X1 is H, n is from 1 to 10 and m is from 1 to 10;
- and
- a pharmaceutically acceptable excipient.
A method of inducing vasodilation comprising administering to a subject in need thereof an effective amount of a fatty acid having a formula:
- wherein X1 is H, n is from 1 to 10 and m is from 1 to 10;
- and
- a pharmaceutically acceptable excipient.
A compound of structure:
- wherein X1 is H, n is from 1 to 10 and m is from 1 to 10;
- and
- a pharmaceutically acceptable excipient.
Dependencies are inferred from the claim text.