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US 10,765,651 B2Granted
Co-crystals of substituted glycine and uses thereof
AssigneeSyneuRx International (Taiwan) Corp.
InventorsGuochuan Emil Tsai, Ching-Cheng Wang, Tien-Lan Hsieh
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Abstract
The present disclosure provides co-crystals of a substituted glycine compound and a co-former compound of Formula (I): compositions comprising such, and uses thereof in treating and/or reducing the risk for a neuropsychiatric disorder (e.g., schizophrenia, psychotic disorders, depressive disorders, suicidal ideation and/or behavior, obsessive compulsive disorder or Alzheimer's disease). Also provided herein are methods for preparing the co-crystals.
Claims13
A co-crystal comprising N-trimethylglycine and a co-former, wherein the co-former is a compound of Formula (IB):
- in which:
- A and B are both H or both OH;
- W is O;
- X is H;
- Z is OH;
- C2C1 are C2═C1 or C2-C1;
- and
- wherein the molecular ratio between the N-trimethylglycine and the co-former in the co-crystal ranges from 1:1 to 2:1.
5 more elements
Dependencies are inferred from the claim text.