Formulation comprising liposomes
AssigneeEisai R&D Management Co., Ltd.
InventorsHiroshi Ishihara, Katsura Hata, Hiroki Muto, Geoff Hird
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Abstract
A formulation comprising liposomes, wherein the liposomes comprise, based on the liposome, 0.7 to 3.0 mol % of eritoran or a pharmaceutically acceptable salt thereof and 0.5 to 3.0 mol % of a PEGylated phospholipid.
Claims21
A formulation comprising liposomes, wherein the liposomes comprise, based on the liposome, 0.7 to 3.0 mol % of eritoran or a pharmaceutically acceptable salt thereof, a PEGylated phospholipid and 0 to 10 mol % of a sterol, wherein the molar ratio range of the eritoran or a pharmaceutically acceptable salt thereof and the PEGylated phospholipid is 1:0.4 to 1:2.5.
A method for producing a formulation comprising liposomes, comprising:
- preparing a solution comprising, based on all components of the liposomes to be used, 0.7 to 3.0 mol % of eritoran or a pharmaceutically acceptable salt thereof, a PEGylated phospholipid, 0 to 10 mol % of a sterol and a solvent, wherein the molar ratio range of the eritoran or a pharmaceutically acceptable salt thereof and the PEGylated phospholipid is 1:0.4 to 1:2.5;
- evaporating the solvent from the solution to form a thin film;
- dispersing the thin film in a buffer solution to form a liquid dispersion;
- and
- extruding the liquid dispersion through a filter to form the formulation.
Dependencies are inferred from the claim text.