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AssigneeCuradigm SAS
InventorsMatthieu Germain, Marie-Edith Meyre, Agnes Pottier, Laurent Levy
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The present invention relates to a pharmaceutical composition comprising the combination of (i) at least one biocompatible nanoparticle and (ii) at least one carrier comprising at least one pharmaceutical compound, to be administered to a subject in need of such a pharmaceutical compound, wherein the combination of the at least one biocompatible nanoparticle and of the at least one carrier comprising the pharmaceutical compound(s) potentiates the compound(s) of interest effectiveness in therapy, prophylaxis or diagnosis. The invention also relates to such a composition for use for administering the pharmaceutical compound(s) in a subject in need thereof, wherein the at least one biocompatible nanoparticle and the at least one carrier comprising the at least one pharmaceutical compound are to be administered separately in a subject in need of said pharmaceutical compound, typically between more than 5 minutes and about 72 hours one from each other.
A method for treating cancer in a subject, the method comprising a step of intravenously administering to the subject at least one carrier comprising at least one pharmaceutical compound, the at least one pharmaceutical compound being encapsulated in the at least one carrier, and the at least one pharmaceutical compound being a chemotherapeutic agent, and a distinct step of intravenously administering to the subject at least one biocompatible lipid-based nanoparticle, wherein the at least one carrier is devoid of any surface sterically stabilizing agent and wherein the longest dimension of the at least one biocompatible nanoparticle is between about 4 nm and about 500 nm, the surface charge value of the at least one biocompatible nanoparticle is a negative surface charge value below −10 mV, the at least one biocompatible nanoparticle is not used as a pharmaceutical compound, and said at least one biocompatible nanoparticle is administered to the subject about 10 minutes, or more than 10 minutes, and less than about 72 hours before administering the at least one carrier comprising the at least one pharmaceutical compound.
Dependencies are inferred from the claim text.