Methods for treatment of charcot-marie-tooth disease with follistatin polypeptides

A method of treating a patient having Charcot-Marie-Tooth disease, the method comprising administering an effective amount of a follistatin fusion protein by an intramuscular route of administration to a targeted muscle of a patient in need thereof, wherein the follistatin fusion protein comprises a first amino acid sequence and a second amino acid sequence, wherein the first amino acid sequence comprises an amino acid sequence that is at least 90% identical to SEQ ID NO:

• 15 or 16, wherein the first amino acid sequence ends at the amino acid corresponding to any one of amino acids 291-302 of SEQ ID NO:
• 4;
• wherein the second amino acid sequence comprises a constant domain of an immunoglobulin G (IgG);
• and wherein the follistatin fusion protein inhibits signaling by myostatin in a cell-based assay.