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US 10,765,625 B2Granted
Knottin-drug conjugates and methods of using the same
AssigneeThe Board of Trustees of the Leland Stanford Junior University
InventorsNicholas Cox, Jennifer R. Cochran, Mark Smith, James R. Kintzing
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Abstract
Provided are knottin-drug conjugates. The conjugates include a knottin peptide that includes an engineered loop that binds to a target on a cancer cell surface, and a drug (e.g., a nucleoside drug) conjugated to the knottin peptide through a linker. Also provided are pharmaceutical compositions and kits that include the knottin-drug conjugates, as well as methods of using the knottin-drug conjugates, e.g., for therapeutic purposes.
Claims33
A knottin-drug conjugate, comprising:
- a knottin peptide comprising an engineered loop that binds to a receptor on a cancer cell surface;
- and
- a chemotherapeutic nucleoside drug conjugated to the knottin peptide through an intracellularly cleavable linker.
A method of making a knottin-drug conjugate, comprising:
- conjugating a chemotherapeutic nucleoside drug to a knottin peptide comprising an engineered loop that binds to a receptor on a cancer cell surface, wherein the chemotherapeutic nucleoside drug is conjugated to the knottin peptide through an intracellularly cleavable linker.
Dependencies are inferred from the claim text.