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US 10,765,616 B2Granted
Oral formulation of polyglucosamine derivatives in combination with a non-fermentable sugar
AssigneeSynedgen, Inc.
InventorsStacy M. Townsend, Shenda M. Baker, William P. Wiesmann
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Abstract
Described herein are methods and compositions that contain a soluble polyglucosamine or polyglucosamine derivative for use in oral health. The compositions are useful for, e.g., reducing bacteria (e.g., by clumping and removing) or disrupting a biofilm in the mouth of a subject, reducing dry mouth, and reducing oral inflammation.
Claims4
A method of treating dry mouth, the method comprising administering to a subject an oral care aqueous composition comprising:
- sorbitol present in the composition at an amount from about 5% to about 35% by weight of the composition;
- xylitol present in the composition at an amount from about 2% to about 15% by weight of the composition;
- and
- a poly (acetyl, arginyl) glucosamine (PAAG), wherein PAAG comprises the following formula (I):
- wherein:
- n is an integer between 20 and 6000;
- and
- each R1 is independently selected for each occurrence from hydrogen, acetyl,
- wherein at least 25% of R1 substituents are H, at least 1% of R1 substituents are acetyl, and at least 2% of R1 substituents are
- the molecular weight of the PAAG is from 20 to 200 kDa, and wherein the PAAG is present in the composition at an amount of at least 0.003% to about 0.05% w/v of the composition.
7 more elements
Dependencies are inferred from the claim text.