Medication delivery systems and methods

A medication delivery system comprising:

• a medication administration device comprising a body having a discharge end defining a medication discharge port and an opposed actuator end, a medication reservoir containing a medication, and an actuator for ejecting the medication from the reservoir through the discharge port, the actuator extending out of the actuator end of the body, the actuator being linearly moveable from an extended position to a depressed position, the discharge port being sealed when the actuator is in the extended position and the discharge port being open when the actuator is in the depressed position, the actuator being operable to discharge said medication from the reservoir upon axial movement of the actuator from the extended position to the depressed position;
• and
• a container comprising an axially extending side wall and a closed bottom wall defining a cavity having an access opening defined by an end wall portion, the medication administration device being received within the cavity with the discharge end adjacent the bottom wall of the container, a cap hingedly coupled to the container, the cap movable relative to the container between an open position and a closed position, the cap in the closed position is sealably engaged with the container to enclose the medication administration device within the cavity, and a desiccant disposed within the cavity, the desiccant having an annular shape to define an opening to receive the medication discharge port of the medication administration device, wherein the body of the medication administration device includes a radially extending circumferential surface surrounding the actuator and facing away from the closed bottom wall,
• in which the container includes a continuous interior shoulder disposed radially inward from an interior surface of the axially extending side wall of the container, the continuous interior shoulder axially spaced from the closed bottom wall at a distance to securely retain the desiccant between the continuous interior shoulder and the closed bottom wall, in which the desiccant includes an annular notch defined along a radially outer surface of the desiccant, the annular notch configured to receive the continuous interior shoulder when the desiccant is disposed within the container,
• wherein the cap defines a pair of hold down members, wherein, when the cap is in the closed position, the hold down members extend axially from the cap in a direction toward the closed bottom wall and sized to allow at most a predetermined amount of axial movement of the medication administration device in the direction away from the closed bottom wall, wherein each of the hold down members has a contact end surface contactable with the circumferential surface of said medication administration device, radially outside the actuator of the medication administration device, wherein the hold down members are configured to allow each of the contact end surfaces to maintain its relative axial position and radial position relative to the cap and the circumferential surface of said device.

A method for providing a medication delivery system containing a glucagon composition, the method comprising:

• positioning a medication administration device within a container,
• the medication administration device comprising a body having a discharge end defining a medication discharge port and an opposed actuator end, the medication administration device including a medication reservoir containing a glucagon medication, the medication administration device further including an actuator for ejecting said glucagon medication from the reservoir through the discharge port, the actuator extending out of the actuator end of the body, the actuator being linearly moveable from an extended position to a depressed position, the discharge port being sealed when the actuator is in the extended position and the discharge port being open when the actuator is in the depressed position, the actuator being operable to discharge the glucagon medication from the reservoir upon axial movement of the actuator from the extended position to the depressed position;
• the container having a side wall and a closed bottom wall defining a cavity having an access opening defined by an end wall portion, the cavity receiving the medication administration device within the cavity with the discharge end adjacent the closed bottom wall of the container, and a desiccant disposed within the cavity, the desiccant having an annular shape to define an opening to receive the medication discharge port of the medication administration device, in which the container includes a continuous interior shoulder disposed radially inward from an interior surface of the side wall, the continuous interior shoulder axially spaced from the closed bottom wall at a distance to securely retain the desiccant between the continuous interior shoulder and the closed bottom wall, in which the desiccant includes an annular notch defined along a radially outer surface of the desiccant, the annular notch configured to receive the continuous interior shoulder when the desiccant is disposed within the container;
• and
• sealing a cap to the container to provide a hermetic seal enclosing the medication administration device within the cavity, the cap defining one or more hold down members positioned and configured to interfere with movement of the medication administration device to allow at most a predetermined amount of movement of the medication administration device in the direction away from the closed bottom wall without the actuator contacting an axial end surface of the cap.

A medication container and cap assembly for containing a medication administration device, the medication administration device comprising a body having a discharge end defining a medication discharge port and an opposed actuator end, the medication administration device including a medication reservoir containing a medication, the medication administration device further including an actuator for ejecting the medication from the reservoir through the discharge port, the actuator extending out of the actuator end of the body, the actuator being linearly moveable from an extended position to a depressed position, the discharge port being sealed when the actuator is in the extended position and the discharge port being open when the actuator is in the depressed position, the actuator being operable to discharge the medication from the reservoir upon axial movement of the actuator from the extended position to the depressed position, the assembly comprising:

• a container having a side wall and a closed bottom wall defining a cavity having an access opening defined by an end wall portion, the cavity being sized and configured to receive the medication administration device, the medication administration device being receivable within the cavity with the discharge end adjacent the closed bottom wall of the container, and a desiccant disposed within the cavity, the desiccant having an annular shape to define an opening to receive the medication discharge port of the medication administration device, in which the container includes a continuous interior shoulder disposed radially inward from an interior surface of the side wall, the continuous interior shoulder axially spaced from the closed bottom wall at a distance to securely retain the desiccant between the continuous interior shoulder and the closed bottom wall, in which the desiccant includes an annular notch defined along a radially outer surface of the desiccant, the annular notch configured to receive the continuous interior shoulder when the desiccant is disposed within the container;
• and
• a cap coupled to the container by a hinged connection, and configured to mate with the container when in a closed position and provide a hermetic seal to enclose the medication administration device inserted within the cavity, the cap defining a pair of hold down members positioned and configured to interfere with movement of the medication administration device to allow at most a predetermined amount of movement of the medication administration device in the direction away from the closed bottom wall, the hold down members disposed circumferentially away from one another, the hinge connection disposed circumferentially between the two hold down members.