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US 10,762,982 B1Granted
System and method for nucleotide analysis
AssigneeTrace Genomics, Inc.
InventorsDiane Wu, Poornima Parameswaran
Life of this patent
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Abstract
A system and method for the detection of pathogens and other microbes using nucleotide analysis is described. Aligned and unaligned nucleotide sequences are utilized to predict the presence or absence of pathogens and other microbes.
Claims16
A nucleotide sampling system comprising:
- a non-transitory computer-readable storage medium storing instructions, the instructions when executed by one or more processors cause the one or more processors to:
- receive a digitized sample based on soil of a farm, the digitized sample including a plurality of sequences of nucleic acids of a plurality of microbes present in the soil, wherein an identity of each of the plurality of microbes is not yet known;
- determine that a subset of the plurality of sequences includes sequences of nucleotides that align at least in part to nucleotides of one or more known nucleic acid sequences of known microbes;
- determine that a remaining subset of the plurality of sequences includes unaligned sequences, the unaligned sequences aligning to less than a threshold number of nucleotides of known nucleic acid sequences;
- determine a likelihood that at least one of the plurality of microbes is present in the soil based at least in part on the unaligned sequences;
- and
- determine a crop stress indicative of a pathogenic state of the soil according to the at least one of the plurality of microbes.
4 more elements
A method comprising:
- receiving a digitized sample based on soil of a farm, the digitized sample including a plurality of sequences of nucleic acids of a plurality of microbes present in the soil, wherein an identity of each of the plurality of microbes is not yet known;
- determining that a subset of the plurality of sequences includes sequences of nucleotides that align at least in part to nucleotides of one or more known nucleic acid sequences of known microbes;
- determining that a remaining subset of the plurality of sequences includes unaligned sequences, the unaligned sequences aligning to less than a threshold number of nucleotides of known nucleic acid sequences;
- determining a likelihood that at least one of the plurality of microbes is present in the soil based at least in part on the unaligned sequences;
- and
- determining a crop stress indicative of a pathogenic state of the soil according to the at least one of the plurality of microbes.
3 more elements
Dependencies are inferred from the claim text.