Devices and methods for tension measurements and applications of same

A device for measuring a tension of a bio-object construct, comprising:

• a probe;
• a moving mechanism configured to move at least one of the probe and the bio-object construct such that the probe is contactable with the bio-object construct;
• and
• a measuring mechanism configured to determine displacements of the probe and the bio-object construct when the probe is in contact with the bio-object construct to cause the displacement of the probe and the displacement of the bio-object construct, so as to measure the tension of the bio-object construct according to the determined displacements.

A method for measuring a tension of a bio-object construct, comprising:

• positioning a probe in relation to the bio-object construct such that the probe is contactable with the bio-object construct;
• moving at least one of the probe and the bio-object construct to make the probe in contact with the bio-object construct to cause a displacement of the probe and a displacement of the bio-object construct;
• and
• determining displacements of the probe and the bio-object construct so as to measure the tension of the bio-object construct according to the determined displacements.

A system for measuring a tension of at least one bio-object construct, comprising:

• a well plate comprising at least one construct well for fixedly accommodating the at least one bio-object construct and at least one motor well neighboring the at least one construct well;
• a mounting base covering the well plate, comprising a first cover portion covering the at least one construct well and a second cover portion covering the at least one motor well, wherein the first cover portion has a through hole exposing the at least one construct well;
• at least one movable plate disposed on the first cover portion of the mounting base corresponding to the at least one construct well and is movable on the mounting base;
• at least one probe attached to a bottom surface of the least one movable plate and extending downward through the through hole of the first cover portion of the mounting base into the least one construct well;
• and
• at least one motor mounted on the second cover portion of the mounting base corresponding to the at least one motor well,
• wherein the at least one motor is configured to move the movable plate along a straight line, so as to move the at least one probe to be in contact with the at least one bio-object construct;
• and
• wherein the tension of the at least one bio-object construct is measurable by determining displacements of both the at least one probe and the at least one bio-object construct upon contact of the at least one probe with the at least one bio-object construct.