Vaults engineered for hydrophobic drug delivery
AssigneeThe Regents of the University of California
InventorsLeonard H. Rome, Daniel Buehler, Heather D. Maynard
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Abstract
The invention relates to compositions of vault complexes for use as delivery agents for hydrophobic and/or aqueous insoluble therapeutic compounds. In one aspect, provided herein is a vault complex comprising a modified major vault protein (MVP), wherein the modified major vault protein comprises a fusion peptide, wherein said fusion peptide is fused to the N-terminus of the major vault protein, and wherein said peptide provides enhanced sequestering of a hydrophobic and/or aqueous insoluble therapeutic compound within the vault complex.
Claims14
A major vault protein having a non-structural protein 5A (NS5A) amphipathic a-helix structure fused to its N-terminus, wherein the sequence of the major vault protein has at least 90% sequence identity to SEQ ID NO:
- 5.
Dependencies are inferred from the claim text.