Multimodal trail molecules expressed in T cells
AssigneeThe General Hospital Corporation
InventorKhalid Shah
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Abstract
Described herein are novel compositions comprising multimodal TRAIL agents and cells engineered to express such multimodal TRAIL agents, including cells encapsulated in a scaffold or matrix, for use in the treatment of disorders such as cancer.
Claims13
A composition comprising a T cell comprising a nucleic acid encoding a polypeptide comprising a soluble TRAIL fusion protein comprising, in the following N-terminal to C-terminal order, a reporter module, a linker module of at least 8 amino acids, and a therapeutic TRAIL module, wherein said therapeutic TRAIL module comprises the extracellular domain of human TRAIL of SEQ ID NO:
- 1.
Dependencies are inferred from the claim text.