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US 10,675,357 B2Granted
Antibodies having specificity to nectin-4 and uses thereof
AssigneesInserm (Institut National De La Sante Et De La Recherche Medicale), Universite D'Aix-Marseille, Centre National de la Recherche Scientifique (CNRS), Institut Jean Paoli & Irene Calmettes
InventorsMarc Lopez, Daniel Olive
Life of this patent
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Abstract
The present invention relates to antibodies having specificity to nectin-4 and uses thereof.
Claims14
An antibody having specificity to nectin-4 and having
- a heavy chain comprising i) the H-CDR1 of N41mab, ii) the H-CDR2 of N41mab and iii) the H-CDR3 of N41mab and
- a light chain comprising i) the L-CDR1 of N41mab, ii) the L-CDR2 of N41mab and iii) the L-CDR3 of N41mab
- wherein
- the H-CDR1 of N41mab is defined by the sequence ranging from the amino acid residue at position 31 to the amino acid residue at position 35 in SEQ ID NO:1,
- the H-CDR2 of N41mab is defined by the sequence ranging from the amino acid residue at position 50 to the amino acid residue at position 65 in SEQ ID NO:1,
- the H-CDR3 of N41mab is defined by the sequence ranging from the amino acid residue at position 98 to the amino acid residue at position 105 in SEQ ID NO:1,
- the L-CDR1 of N41mab is defined by the sequence ranging from the amino acid residue at position 24 to the amino acid residue at position 34 in SEQ ID NO:2,
- the L-CDR2 of N41mab is defined by the sequence ranging from the amino acid residue at position 50 to the amino acid residue at position 56 in SEQ ID NO:2, and
- the L-CDR3 of N41mab is defined by the sequence ranging from the amino acid residue at position 89 to the amino acid residue at position 96 in SEQ ID NO:2.
6 more elements
Dependencies are inferred from the claim text.