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US 10,675,304 B2Granted
Combination immunotherapies for treatment of cancer
AssigneePrimevax Immuno-Oncology, Inc.
InventorBruce W. Lyday
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Abstract
Described herein are compositions and methods for treating a disease, particularly a cancer, with an immune checkpoint modulatory agent and a strain of an Arbovirus or a strain of an Alphavirus. Also provided herein are also methods for combination therapy comprising administration of an immune checkpoint modulatory agent, tumor antigen primed dendritic cells and an Alphavirus or an Arbovirus.
Claims14
A method for treatment or reduction of cancer in a subject in need thereof, comprising administering:
- a) a Dengue virus of serotype 1 (DENV-1), wherein the DENV-1 is strain 45AZ5;
- b) an immune checkpoint modulatory agent;
- and
- c) tumor antigen primed dendritic cells.
1 more element
Dependencies are inferred from the claim text.