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US 10,626,394 B2Granted
Synthetic bacteriophages and bacteriophage compositions
AssigneeMassachusetts Institute of Technology
InventorsTimothy Kuan-Ta Lu, Sebastien Lemire, Andrew C. Yang, Kevin M. Yehl
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Abstract
Disclosed herein are novel synthetic bacteriophages and bacteriophage compositions, methods of production thereof, and therapeutic uses thereof.
Claims18
A synthetic bacteriophage comprising mutations in a tail fiber tip protein, wherein the mutations:
- (i) are engineered in one or more binding loops of the tail fiber tip protein, wherein the binding loops face the basal or apex side of the tail fiber;
- and (ii) cause the bacteriophage to have a different host range than the corresponding bacteriophage lacking the mutations in the tail fiber tip protein.
A method of producing one or more synthetic bacteriophages comprising mutating a tail fiber protein of a bacteriophage wherein the mutations:
- (i) are engineered in one or more binding loops of the tail fiber tip protein, wherein the binding loops face the basal or apex side of the tail fiber;
- and (ii) cause the bacteriophage to have a different host range than the corresponding bacteriophage lacking the mutations in the tail fiber tip protein.
Dependencies are inferred from the claim text.