Use of MVA or MVAΔE3L as immunotherapeutic agents against solid tumors
AssigneeMemorial Sloan Kettering Cancer Center
InventorsLiang Deng, Jedd Wolchok, Taha Merghoub, Stewart Shuman, Peihong Dai, Weiyi Wang
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Abstract
The present disclosure relates to modified vaccinia Ankara (MVA) virus or MVAAE3L delivered intratumorally or systemically as an anticancer immunotherapeutic agent, alone, or in combination with one or more immune checkpoint blocking agents for the treatment of malignant solid tumors. Particular embodiments relate to mobilizing the host's immune system to mount an immune response against the tumor.
Claims18
A method for treating a malignant solid tumor in a subject in need thereof, the method comprising delivering to the cells of the tumor a therapeutically effective amount of a modified vaccinia Ankara virus with deletion of vaccinia virulence factor E3 (MVAΔE3L), thereby resulting in the treatment of the tumor, wherein the tumor is melanoma or colon carcinoma.
A method for treating a malignant tumor in a subject in need thereof, the method comprising delivering to tumor cells of the subject a therapeutically effective amount of a modified vaccinia Ankara virus with deletion of vaccinia virulence factor E3 (MVAΔE3L), and conjointly administering to the subject a therapeutically effective amount of an immune checkpoint blocking agent or an immune checkpoint agonist, wherein the tumor is melanoma or colon carcinoma.
A composition for use in treating a solid tumor in a subject in need thereof comprising a therapeutically effective amount of a modified vaccinia Ankara virus with deletion of vaccinia virulence factor E3 (MVAΔE3L), and a pharmaceutically acceptable carrier or diluent, wherein the MVAΔE3L does not comprise a heterologous nucleic acid encoding or expressing a tumor antigen, wherein the tumor is melanoma or colon carcinoma.
Dependencies are inferred from the claim text.