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US 10,504,223 B2Granted
Cell image evaluation device, method, and program
AssigneeFUJIFILM Corporation
InventorsKenta Matsubara, Tsuyoshi Matsumoto
Life of this patent
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Abstract
A cell image evaluation device includes an image acquisition unit that acquires a captured image of a cell, a cell evaluation unit that evaluates the cell image, and a maturity information acquisition unit that acquires information related to maturity of the cell. The cell evaluation unit determines a method for evaluating the cell image on the basis of the information related to the maturity.
Claims11
A cell image evaluation device comprising:
- a memory;
- and
- a processor that is connected to the memory and that is configured to:
- acquire an observation image of cells captured by an imaging device;
- acquire information related to maturity of the cells;
- and
- evaluate undifferentiation and differentiation of the cells using the observation image, according to evaluation criteria of the cells corresponding to the maturity of the cells and a culture condition of the cells,
- wherein the information related to maturity is contained in the observation image that is a target for evaluation and the information related to maturity is a period of time from a time of seeding the cells,
- wherein, based on the information related to maturity, a combination of types of the evaluation criteria that is used for evaluating a differentiation or an undifferentiation of the observation image is changed, and, based on the information related to maturity, a weight that is respectively added to the plurality of the evaluation criteria that is used for evaluating the observation image is changed, and
- wherein, in a case in which the maturity is in an initial stage of seeding, the processor performs a process of extracting a cell colony from the observation image when the culture condition is a colony seeding method of seeding the cells by cell colony and estimates the cell colony from the cells in the observation image when the culture condition is a single cell seeding method of seeding the cells by cell.
7 more elements
A cell image evaluation method comprising:
- when an observation image of cells is acquired and evaluated, acquiring information related to maturity of the cells, the information related to maturity being contained in the observation image that is a target for evaluation and the information related to maturity is a period of time from a time of seeding the cell;
- and
- determining a method for evaluating undifferentiation and differentiation of the cells using the observation image, according to evaluation criteria of the cells corresponding to the maturity of the cells and a culture condition of the cells,
- wherein, based on the information related to maturity, a combination of types of the evaluation criteria that is used for evaluating a differentiation or an undifferentiation of the observation image is changed, and, based on the information related to maturity, a weight that is respectively added to the plurality of the evaluation criteria that is used for evaluating the observation image is changed,
- wherein, in a case in which the maturity is in an initial stage of seeding, extracting a cell colony from the observation image when the culture condition is a colony seeding method of seeding the cells by cell colony and estimating the cell colony from the cells in the observation image when the culture condition is a single cell seeding method of seeding the cells by cell.
2 more elements
A non-transitory computer readable recording medium having a cell image evaluation program stored therein, that causes a computer to perform the following functions:
- acquire an observation image of cells;
- acquire information related to maturity of the cell;
- and
- evaluate undifferentiation and differentiation of the cells using the observation image, according to evaluation criteria of the cells corresponding to the maturity of the cells and a culture condition of the cells,
- wherein the information related to maturity is contained in the observation image that is a target for evaluation and the information related to maturity is a period of time from a time of seeding the cells,
- wherein, based on the information related to maturity, a combination of types of the evaluation criteria that is used for evaluating a differentiation or an undifferentiation of the observation image is changed, and, based on the information related to maturity, a weight that is respectively added to the plurality of the evaluation criteria that is used for evaluating the observation image is changed, and
- wherein, in a case in which the maturity is in an initial stage of seeding, extracting a cell colony from the observation image when the culture condition is a colony seeding method of seeding the cells by cell colony and estimating the cell colony from the cells in the observation image when the culture condition is a single cell seeding method of seeding the cells by cell.
4 more elements
Dependencies are inferred from the claim text.