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AssigneeVentana Medical Systems, Inc.
InventorsSrinivas Chukka, Anindya Sarkar, Quan Yuan
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The disclosure relates to devices, systems and methods for image registration and annotation. The devices include computer software products for aligning whole slide digital images on a common grid and transferring annotations from one aligned image to another aligned image on the basis of matching tissue structure. The systems include computer-implemented systems such as work stations and networked computers for accomplishing the tissue-structure based image registration and cross-image annotation. The methods include processes for aligning digital images corresponding to adjacent tissue sections on a common grid based on tissue structure, and transferring annotations from one of the adjacent tissue images to another of the adjacent tissue images. The basis for alignment may be a line-based registration process, wherein sets of lines are computed on the boundary regions computed for the two images, where the boundary regions are obtained using information from two domains—soft-weighted foreground images and gradient magnitude images. The binary mask image, based on whose boundary the line features are computed, may be generated by combining two binary masks—a first binary mask is obtained on thresholding a soft-weighted (continuous valued) foreground image, which is computed based on the stain content in an image, while a second binary mask is obtained after thresholding a gradient magnitude domain image, where the gradient is computed from the grayscale image obtained from the color image.
A computerized process, comprising:
A method for snapping an annotation from a first digital image from a set of digital images of adjacent tissue sections to a second digital image of the set of digital images of adjacent tissue sections, comprising:
A computer-readable medium storing instructions which, when executed by one or more processors of a computing device, cause the computing device to perform a line-based tissue matching image registration process to globally align a first image and a second image to a common grid, wherein the first image is a digital image of a tissue section and the second image is a digital image of an adjacent tissue section, and wherein the line-based tissue matching image registration process comprises a coarse registration mode comprising:
A computing system comprising one or more processors and coupled to one or more memory devices, the one or more memory devices storing instructions which, when executed by the one or more processors, cause the computing system to perform a line-based tissue matching image registration process to globally align a first image and a second image to a common grid, wherein the first image is a digital image of a tissue section and the second image is a digital image of an adjacent tissue section, and wherein the line-based tissue matching image registration process comprises a coarse registration mode comprising:
Dependencies are inferred from the claim text.