Polymers and nanogel materials and methods for making and using the same

An ophthalmic solution comprising at least one water soluble, cross-linked copolymer comprising a plurality of primary polymer chains each having a degree of polymerization in the range of about 10 to about 10,000, wherein said copolymer is present in an amount effective to inhibit lipid uptake in a contact lens which is soaked in said solution and said ophthalmic solution is transparent, and wherein said water soluble, crosslinked polymers has primary chains, ζ, represented by the formula

• wherein R1 is a divalent group selected from the group consisting of optionally substituted alkylene;
• optionally substituted saturated, unsaturated or aromatic carbocyclic or heterocyclic rings;
• optionally substituted alkylthio;
• optionally substituted alkoxy;
• or optionally substituted dialkylamino;
• U is independently selected from the group consisting of hydrogen, halogen, C1-C4 alkyl which may be optionally substituted with hydroxyl, alkoxy, aryloxy (OR″), carboxy, acyloxy, aroyloxy (O2CR″), alkoxy-carbonyl, aryloxy-carbonyl (CO2R″) and combinations thereof,
• V is independently selected from the group consisting of R″, —CO2R″, —COR″, —CN, —CONH2, —CONHR″, —CONR″2, —O2CR″, —OR″, cyclic and acyclic N-vinyl amides and combinations thereof;
• R′ is independently selected from the group consisting of optionally substituted C1-C18 alkyl, C2-C18 alkenyl, aryl, heterocyclyl, alkaryl wherein the substituents are independently selected from the group that consists of epoxy, hydroxyl, alkoxy, acyl, acyloxy, carboxy, carboxylate, sulfonic acid, and sulfonate, alkoxy- or aryloxy-carbonyl, isocyanato, cyano, silyl, halo, dialkylamino;
• phosphoric acids, phosphates, phosphonic acids, phosphonates and combinations thereof;
• R15′ and R15 are residues of hydrophilic, free radical reactive cross-linking agents;
• R18 is a controlled radical polymerization agent;
• ζl is another primary chain, are mole fractions, and α is equal to about 0.85 to about 0.999, β is not 0, and the mole fractions of β and γ combined are about 0.15 to about 0.001.