Systems and methods using biomarker panel data

A method of treating a patient that is receiving CRT therapy:

• selecting a patient that is receiving CRT therapy;
• quantifying levels of a panel of biomarkers in a biological sample of the patient;
• analyzing the quantified levels to determine an expected response to CRT therapy with an external medical device comprising a microprocessor, wherein the microprocessor
• compares the expected response to CRT therapy to the patient's actual response to CRT therapy;
• and
• adjusts parameters of the CRT therapy if the patient's actual response to CRT therapy is worse than the expected response to CRT therapy;
• the panel of biomarkers comprising at least CRP, sST2, TIMP-1, and TIMP-2.

A method of treating a patient with CRT therapy comprising:

• selecting a patient exhibiting heart failure symptoms and lacking a CRT device;
• quantifying levels of a panel of biomarkers in a biological sample of the patient;
• analyzing the quantified levels to determine response to CRT therapy with an external medical device comprising a microprocessor, wherein the microprocessor
• analyzes the quantified levels comprising comparing quantified levels to threshold levels to determine likelihood of response to CRT therapy;
• and
• places the patient into one of a set of categories using the quantified levels, the set of categories including at least one of CRT therapy responders, CRT therapy non-responders, and indeterminate response;
• treating the patient with a CRT device if the patient is in the CRT therapy responders category;
• the panel of biomarkers comprising at least CRP, sST2, TIMP-1, and TIMP-2.