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US 10,502,737 B2Granted
Anti-thrombotic compositions and methods for assaying platelet reactivity and treatment selection
AssigneeThe University of Vermont and State Agriculture College
InventorDavid Schneider
Life of this patent
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Abstract
Compositions and methods are provided for determining platelet reactivity where the levels of FcγRIIa on the surface of platelets is measured and if the levels of FcγRIIa are greater than a reference value, the platelets have enhanced reactivity.
Claims5
A method of treating a selected subject at risk of thrombosis with an anti-thrombotic therapy, the method comprising:
- administering an anti-thrombotic agent that is an Adenosine diphosphate (ADP) receptor antagonist and/or a Protease-activated receptor (PAR) antagonist to the selected subject, wherein the subject is selected by
- determining a level of FcγRIIa expressed on platelets from the subject, wherein a level greater than about 7,500 copies of FcγRIIa per platelet identifies the subject at risk of thrombosis and in need for anti-thrombotic therapy.
Dependencies are inferred from the claim text.