System for biodetection applications

A system for biodetection applications comprising:

• a. a substrate of dielectric material having at least one surface functionalized with a recognition element which can bind specifically to a target analyte, the dielectric material being surrounded by a surrounding material wherein the substrate acts as a mechanical resonator and optical cavity;
• and
• b. at least one nanoparticle with plasmonic properties which comprises at least one detection element bound thereto and which can bind specifically to the target analyte in a sandwich-type arrangement,
• characterized in that:
• the substrate of dielectric material has a thickness between 0.1 μm and 5 μm and an extinction coefficient less than 0.3,
• the nanoparticle has at least one of its dimensions with a size of 2 nm to 300 nm,
• the ratio between the refractive index of the dielectric material and the surrounding material is greater than 1.1, and
• in that the system detection is performed by an optoplasmonic detection of an enhanced plasmonic effect.