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US 10,502,729 B2Granted
Diagnostic methods, therapeutic agents and uses thereof
AssigneeMetabolon, Inc.
InventorsLuke Miller, Klaus Peter Adam, Michael V. Milburn, Jeffery E. Cobb, Anne M. Evans, Qibo Zhang
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Abstract
The present invention provides a method for diagnosing a disease or disorder selected from the group consisting of insulin resistance, a metabolic disorder, diabetes and pre-diabetes in a subject. The method comprises the step of determining the level of a compound represented by structural formula (VI): or a salt thereof. Compositions and method of making thereof are also described.
Claims6
A method of preparing a compound represented by the following formula:
- or a salt thereof, comprising the steps of:
- (1) isolating a compound of formula 3 from Ailanthus triphysa
- (2) reacting the compound of formula 3 with an oxidizing reagent to give a compound of formula 4:
- (3) reacting the compound of formula 4 with a reducing reagent to give a compound of formula 5:
- (4) reacting the compound of formula 5 with sulfuric acid to give the compound of formula (VII).
2 more elements
Dependencies are inferred from the claim text.