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US 10,502,720 B2Granted
Methods for liquid chromatography calibration for rapid labeled N-glycans
AssigneeWaters Technologies Corporation
InventorsMichael F. Morris, Matthew A. Lauber, Darryl W. Brousmiche
Life of this patent
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Abstract
Methods are provided for making rapid labeled dextran ladders and other calibrants useful in liquid chromatography. The methodologies include a two-step process comprising a reductive amination step of providing a reducing glycan and reacting it with a compound having a primary amine to produce an intermediate compound. The intermediate compound is then rapidly tagged with a rapid tagging reagent to produce the rapid labeled dextran ladder.
Claims1
A calibrant of the structural formula:
- wherein R is a glucose unit or a monosaccharide unit.
Dependencies are inferred from the claim text.