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US 10,501,806 B2Granted
Chromosomal assessment to differentiate histiocytic malignancy from lymphoma in dogs
AssigneeNorth Carolina State University
InventorMatthew Breen
Life of this patent
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Abstract
This invention relates generally to the discovery of an improved method to differentiate histiocytic malignancy from lymphoma or hemangiosarcoma in dogs.
Claims16
A method for treating a dog with lymphoma, the method comprising:
- (a) measuring copy numbers of CFA 2, CFA 16, and CFA 31 in a biological sample from a dog suspected of having lymphoma or a histiocytic malignancy, wherein:
- (i) the biological sample comprises neoplastic cells;
- and
- (ii) the copy numbers of CFA 2, CFA 16, and CFA 31 are measured by aberrations at CFA chr2:31,017,808-31,586,959, CFA chr16:31,674,246-32,429,051, and CFA chr31:33,346,317-33,709,291 from CamFam2, respectively;
- (b) detecting a normal or elevated copy number at CFA 2, CFA 16, and CFA 31 compared to a normal control in the biological sample;
- (c) diagnosing the dog with lymphoma;
- and
- (d) treating the dog with standard of care (SOC) chemotherapy using either single agent or multiagent protocols.
5 more elements
A method for selecting and treating a dog suspected of having a canine lymphoma, the method comprising:
- (a) providing a dog suspected of having a lymphoma or a histiocytic malignancy;
- (b) measuring copy numbers of CFA 2, CFA 16, and CFA 31 in a biological sample from the dog, wherein:
- (i) the biological sample comprises cells obtained directly from a suspected neoplastic mass;
- and
- (ii) the copy numbers of CFA 2, CFA 16, and CFA 31 are measured by aberrations at CFA chr2:31,017,808-31,586,959, CFA chr16:31,674,246-32,429,051, and CFA chr31:33,346,317-33,709,291 from CamFam2, respectively;
- (b) detecting normal or elevated copy number at CFA 2, CFA 16, and CFA 31 compared to a normal control in the biological sample;
- (c) diagnosing the dog with lymphoma;
- and
- (d) treating the dog with standard of care (SOC) chemotherapy using either single agent or multiagent protocols.
6 more elements
Dependencies are inferred from the claim text.