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US 10,501,771 B2Granted
Methods and uses for metabolic profiling for Clostridium difficile infection
AssigneeBoard of Regents, The University of Texas System
InventorsTor Savidge, Sara Dann
Life of this patent
Estimating the term…
Abstract
Embodiments include methods for generating a metabolite profile of a stool sample and methods of assessing the status of a subject using the metabolic profile derived from a stool sample.
Claims6
A method of treating a subject having a Clostridium difficile infection (CDI) comprising:
- measuring levels of gamma-aminobutyrate (GABA), ammonia, or GABA and ammonia, in a stool sample from a subject;
- and
- administering a treatment for CDI to the subject if the levels of the one or more biomarkers are elevated compared to a reference level.
A method of treating a subject having a recurrent Clostridium difficile infection (CDI) comprising:
- distinguishing a subject having recurrent Clostridium difficile infection from a subject having a non-recurrent Clostridium difficile infection comprising measuring levels of one or more biomarkers selected from ammonia or gamma-aminobutyrate (GABA) in a stool sample and identifying a subject having a recurrent CDI if one or more biomarkers are elevated more than 200% compared to a non-infected control level;
- and
- administering a treatment for CDI to the subjects identified as having recurrent CDI.
Dependencies are inferred from the claim text.