Bacteria carrying bacteriophage and protease inhibitors for the treatment of disorders and methods of treatment
OwnerDavid Gordon Bermudesinventor
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Abstract
The present invention uses co-expression of protease inhibitors and protease sensitive therapeutic agents including phage and phagemids delivering peptides, therapeutic antibodies, DNA and RNA-based therapeutics that results in treating inflammation of a variety of disorders including psoriasis, atopic dermatitis and inflammatory bowel disease. The invention also provides bacteria that inhibit the growth of intestinal parasites such as worms, and deliver siRNA or miRNA that have specific anti-parasitic effects that results in the reduction or elimination of the parasite.
Claims12
A pharmaceutically acceptable delivery vehicle for a therapeutic agent to treat a eukaryotic disease of a eukaryotic organism, comprising:
- a live bacterium;
- and
- a capsid surrounding a first nucleic acid, selected from the group consisting of a phage, a phagemid and a viroid, produced by the live bacterium,
- the first nucleic acid comprising a nucleic acid sequence adapted to cause a eukaryotic cell of the eukaryotic organism, after receipt of the first nucleic acid, to produce a corresponding second nucleic acid effective for treating the eukaryotic disease of the eukaryotic organism wherein the corresponding second nucleic acid encodes a heterologous chimeric peptide.
Dependencies are inferred from the claim text.