Methods and compositions for inhibiting growth and epithelial to mesenchymal transition (EMT) in cancer cells
AssigneesCold Spring Harbor Laboratory, Rutgers, The State University of New Jersey
InventorsRaffaella Sordella, Serif Senturk, Luca Cartegni, Zhan Yao
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Abstract
Provided herein are methods and compositions for inhibiting epithelial to mesenchymal transition of a cell.
Claims25
A method of inhibiting cancer cells, comprising:
- (a) determining whether cancer cells express p53Ψ, wherein the cancer cells are in a population of cells;
- and
- (b) if the cancer cells in (a) express p53Ψ, administering a cyclophilin D (CypD) inhibitor in an effective amount that results in inhibition of p53Ψ protein activity.
A method of inhibiting growth of cancer cells in an individual, comprising:
- (a) assessing cells in a population of cells obtained from an individual for expression of p53Ψ;
- (b) identifying the cells from (a) that express p53Ψ;
- and
- (c) if the cells assessed in (a) express p53Ψ, administering to the individual from whom the population of cells was obtained, a cyclophilin D (CypD) inhibitor in an effective amount that inhibits growth of cancer cells in the individual.
A method of treating an individual who has cancer cells that express p53Ψ, comprising administering to the individual in need thereof a CypD inhibitor in an effective amount that results in inhibition of p53Ψ.
A method of identifying an individual suffering from cancer as a candidate for treatment with a CypD inhibitor, comprising
- (a) determining whether cancer cells from the individual are CD44+ and CD24−;
- (b) determining whether the cancer cells from the individual express p53Ψ;
- (c) identifying the individual as a candidate for treatment if the cancer cells in (a) and (b) are CD44+ and CD24− and express p53Ψ;
- and
- (d) administering to the individual who has been identified as a candidate for treatment, a CypD inhibitor in an effective amount that results in inhibition of p534Ψ activity.
Dependencies are inferred from the claim text.