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US 10,501,731 B2Granted
Degradable clostridial toxins
AssigneeAllergan, Inc.
InventorsLance E. Steward, Sanjiv Ghanshani, Ester Fernandez-Salas, Marcella A. Gilmore, Joseph Francis, Kei Roger Aoki
Life of this patent
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Abstract
The specification discloses Clostridial toxins or Clostridial toxin chimeras comprising an inactivation cleavage site, polynucleotide molecules encoding such toxins or chimeras, compositions comprising such toxins or chimeras, and method of producing such toxins or chimeras.
Claims3
A non-naturally occurring Clostridial toxin comprising at least one exogenous protease cleavage site located within an inactivation cleavage site region, wherein the inactivation cleavage site region is located
- in the translocation domain and/or the N-terminal subdomain of the binding domain (HCN), wherein the at least one exogenous protease cleavage site comprises a dual Thrombin-Thrombin cleavage site, a Factor Xa cleavage site, a dual Factor Xa-Thrombin cleavage site, and/or a Matrix Metalloproteinase-9 (MMP-9) cleavage site, and
- wherein the inactivation cleavage site region comprises a variant of SEQ ID NO:1 comprising the at least one exogenous protease site in amino acids 871-895 of SEQ ID NO:
- 1.
Dependencies are inferred from the claim text.