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US 10,501,729 B2Granted
Engineered heme-binding compositions and uses thereof
AssigneePresident and Fellows of Harvard College
InventorsMichael Super, Alexander L. Watters, Philip T. Snell, Donald E. Ingber
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Abstract
Described herein are heme-binding compositions and methods relating to their use, for example methods of treatment of sepsis and rhabdomyolysis.
Claims18
A composition comprising:
- an engineered heme-binding fusion protein comprising:
- a hemopexin domain comprising a polypeptide having a sequence corresponding to residues 27-213 of SEQ ID NO:
- 1 or SEQ ID NO:
- 2;
- and
- a Fc domain comprising the polypeptide sequence of SEQ ID NO:
- 8, SEQ ID NO:
- 7, or SEQ ID NO:
- 17.
6 more elements
Dependencies are inferred from the claim text.