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US 10,501,630 B2Granted
Rhodamine dyes and conjugates
AssigneePharmacophotonics, Inc.
InventorsUlf J. Bremberg, Erik Ringberg, Wei Berts, Anthony De Belder, James S. Strickland
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Abstract
The present invention relates generally to novel rhodamine dyes which upon conjugation with another molecule form single isomeric conjugation products. These novel rhodamine dyes contain only one single functional group on the rhodomine molecule for conjugation so that their conjugation products are single isomeric conjugation products.
Claims22
A compound comprising a rhodamine dye or a salt thereof having the general structure of
- wherein:
- R5 is independently H,
- R4 is independently H,
- R3 is independently H,
- R2 is independently H or
- and R1 is H, provided that only one of R2, R3, R4 and R5 is not H,
- wherein the rhodamine dye is capable of conjugating with another molecule via the functional group;
- and wherein the Ar on one or more of the substituents is an aryl group and the R6 or R7 on the substituents form a spacer which contains a single functional group on either R6 or R7 suitable for conjugation with another molecule.
5 more elements
Dependencies are inferred from the claim text.