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US 10,501,581 B2Granted
Sequence-defined polymers and methods of making same and using same
AssigneeCornell University
InventorsChristopher Akinleye Alabi, Mintu Porel
Life of this patent
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Abstract
Methods of making sequence-defined polymers and sequence-defined polymers. The methods are based on the orthogonal reactivity of monomers having at least two different functional groups. The sequence-defined polymers can be used in various applications. For example, the SDPs (e.g., pH sensitive SDPs) are used in cell lysis methods or as molecular vehicles to transport drug cargo into cells.
Claims11
A method of making a sequence-defined polymer (SDP) having 3 to 50 monomers comprising:
- a) contacting a first monomer having a free allyl group or a free acrylamide group and a first co-monomer having two thiol groups capable of reacting with the allyl group and the acrylamide group of the first monomer under conditions such that the allyl group or acrylamide group reacts with one of the thiol groups on the co-monomer to form a first SDP reaction product;
- b) contacting the first SDP reaction product with a second monomer having an allyl group and an acrylamide group such that i) the acrylamide group of the second monomer reacts with the unreacted thiol group of the first SDP reaction product without substantial reaction of the allyl group of the second monomer or ii) the allyl group of the second monomer reacts with the unreacted thiol group of the first SDP reaction product without substantial reaction of the acrylamide group of the second monomer to form a second SDP reaction product;
- c) optionally, contacting the second SDP reaction product with a second co-monomer having two thiol groups such that i) if the allyl group of the second monomer reacted in b), the acrylamide group of the second SDP product reacts with one of the thiol groups of the second co-monomer or ii) if the acrylamide group of the second monomer reacted in b), the allyl group of the second SDP product reacts with one of the thiol groups of the second co-monomer to form a third SDP reaction product;
- d) optionally, contacting the third SDP reaction product with a third monomer having an allyl group and an acrylamide group such that i) the acrylamide group of the third monomer reacts with the unreacted thiol group of the third SDP reaction product without substantial reaction of the allyl group of the third monomer or ii) the allyl group of the third monomer reacts with the unreacted thiol group of the third SDP reaction product without substantial reaction of the acrylamide group of the third monomer to form a fourth SDP reaction product;
- and
- e) optionally, repeating c) and d) from 1 to 47 times such that a sequence-defined polymer is formed.
3 more elements
Dependencies are inferred from the claim text.