Poloxamer composition free of long circulating material and methods for production and uses thereof

A long circulating material free (LCMF) poloxamer 188, wherein:

• the LCMF poloxamer 188 is a polyoxyethylene/polyoxypropylene copolymer that has the formula HO(CH2CH2O)a′—[CH(CH3)CH2O]b—(CH2CH2O)aH, wherein:
• each of a and a′ is an integer such that the percentage of the hydrophile (C2H4O) is between approximately 60% and 90% by weight of the total molecular weight of the copolymer;
• a and a′ are the same or different;
• b is an integer such that the molecular weight of the hydrophobe (C3H6O) is between approximately 1,300 and 2,300 Daltons;
• no more than 1.5% of the total components in the polymeric distribution of the co-polymer are low molecular weight components having an average molecular weight of less than 4,500 Daltons;
• no more than 1.5% of the total components in the polymeric distribution of the co-polymer are high molecular weight components having an average molecular weight of greater than 13,000 Daltons;
• the polydispersity value of the copolymer is less than approximately 1.07 or less than 1.07;
• and
• following intravenous administration to a human subject, the circulating plasma half-life of any components not comprising the main peak in the distribution of copolymer is no more than 5.0-fold the circulating half-life of the main component in the distribution of the copolymer.