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US 10,501,553 B2Granted
Methods and compositions for cancer treating conditions relating to over expressions of EphA2
OwnerDimitar B Nikolov, Juha Himanen +2inventors
InventorsDimitar B Nikolov, Juha Himanen, Urpo Lamminmaki, Hanna Sanmark
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Abstract
An anti-EphA2 scFv single-chain antibody binds with high specificity for EphA2 and blocks ephrin binding to Eph-A2. The antibody may be linked with other antigen-targeting domains, such as an anti-CD20 domain, or conjugated with toxins, or used in combination therapy to for treatment of conditions related to overexpression of EphA2. The antibody may also be expressed in vivo by an expression vector that is designed to facilitate such treatment.
Claims27
A protein comprising an anti-EphA2 scFv domain comprising the amino acid sequence of SEQ ID NO:
- 1, 5, 6 or 7.
Dependencies are inferred from the claim text.