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US 10,501,538 B2Granted
Anti-LILRB antibodies and their use in detecting and treating cancer
AssigneeBoard of Regents, The University of Texas System
InventorsChengcheng Zhang, Mi Deng, Wei Xiong, Zhiqiang An, Ningyan Zhang, Xun Gui, Junke Zheng
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Abstract
The present disclosure is directed to antibodies binding to LILRBs and methods of detecting and treating cancer therewith.
Claims24
An isolated monoclonal antibody or an antigen-binding fragment that binds to LILRB4 thereof comprising:
- (a) a heavy chain variable region comprising the complementary determining regions (CDRs) of SEQ ID NOS:
- 73, 74 and 75 in that order;
- and
- a light chain variable region comprising the CDR of SEQ ID NO:
- 76, TAS and SEQ ID NO:
- 77 in that order;
- (b) a heavy chain variable region comprising the CDRs of SEQ ID NOS:
- 83, 84 and 85 in that order;
- and a light chain variable region comprising the CDRs of SEQ ID NO:
- 86, RAS and SEQ ID NO:
- 87 in that order;
- (c) a heavy chain variable region comprising the CDRs of SEQ ID NOS:
- 98, 99 and 100 in that order;
- and a light chain variable region comprising the CDRs of SEQ ID NO:
- 101, EAS and SEQ ID NO:
- 102 in that order;
- or
- (d) a heavy chain variable region comprising the CDRs of SEQ ID NOS:
- 166, 167 and 168 in that order;
- and a light chain variable region comprising the CDRs of SEQ ID NOS:
- 169, 170 and 171 in that order.
18 more elements
Dependencies are inferred from the claim text.