Methods for treating cancer
AssigneeDana-Farber Cancer Institute, Inc.
InventorKwok-Kin Wong
Life of this patent
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Abstract
The present invention provides methods of treating cancer, particularly cancers that had developed resistance to PD-1 and PDL-1 blockade. Also included are methods of identifying therapeutic targets for the treatment of cancer.
Claims13
A method of treating a subject with a cancer that has acquired resistance to a PD-1 or PDL-1 immunotherapy, comprising administering to said subject an antibody that inhibits the expression or activity of a T cell immunoglobulin and mucin protein 3 (Tim3) and a PD-1 or PDL-1 immunotherapy.
A method of deriving a clinical benefit from a PD-1 or PDL-1 immunotherapy in a subject with a cancer that has acquired resistance to PD-1 or PDL-1 immunotherapy, comprising administering to said subject an antibody that inhibits the expression or activity of a T cell immunoglobulin and mucin protein 3 (Tim3) and a PD-1 or PDL-1 immunotherapy.
Dependencies are inferred from the claim text.