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US 10,501,535 B2Granted
Antibody targeting stem cell factor
AssigneeThe Regents of the University of Michigan
InventorsNicholas W. Lukacs, Steven L. Kunkel, Cory Hogaboam
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Abstract
Provided herein are methods, compositions, and uses relating to inhibitors of stem cell factor. For example, provided herein are antibodies targeting stem cell factor and methods for treating fibrotic and tissue remodeling diseases.
Claims7
An isolated recombinant monoclonal anti-stem cell factor (SCF) antibody comprising:
- (a) a light chain variable domain comprising an amino acid sequence comprising:
- (i) a first amino acid sequence comprising the CDR1 sequence provided by amino acids 42-53 of SEQ ID NO:
- 4;
- a second amino acid sequence comprising the CDR2 sequence provided by amino acids 69-79 of SEQ ID NO:
- 4;
- and
- (iii) a third amino acid sequence comprising the CDR3 sequence provided by amino acids 112-124 of SEQ ID NO:
- 4;
- and
- (b) a heavy chain variable domain comprising an amino acid sequence comprising:
- (i) a first amino acid sequence comprising the CDR1 sequence provided by amino acids 45-56 of SEQ ID NO:
- 2;
- a second amino acid sequence comprising the CDR2 sequence provided by amino acids 71-86 of SEQ ID NO:
- 2;
- and
- (iii) a third amino acid sequence comprising the CDR3 sequence provided by amino acids 119-123 of SEQ ID NO:
- 2.
14 more elements
Dependencies are inferred from the claim text.