Probiotics, secretory IgA and inflammation
AssigneeSociete des Produits Nestle S.A.
InventorsJalil Benyacoub, Blaise Corthesy, Stephanie Blum-Sperisen, Laurent Favre
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Abstract
Probiotics and ways to increase their effectiveness are provided. One embodiment of the present invention relates to a combination of probiotics with SIgA and possible uses of this combination. For example a use of a composition comprising SIgA and at least one probiotic for the preparation of a product to treat or prevent inflammation is disclosed.
Claims15
A method for reducing the severity of an inflammatory condition selected from the group consisting of inflammatory bowel disease, Crohn's disease, ulcerative colitis, necrotizing enterocolitis, eczema, allergy, and atopy, the method comprising:
- administering a therapeutically-effective amount of a composition comprising isolated secretory immunoglobulin A (SIgA) and a probiotic micro-organism to a subject, wherein the isolated SIgA and the probiotic micro-organism are present in the form of a complex with each other, the isolated SIgA and the probiotic micro-organism are present in the composition in a stoichiometric ratio of a least 10:1, and the composition comprises between 102 and 2×107 cells of the probiotic micro-organism per daily dose.
Dependencies are inferred from the claim text.