Peptide compound
AssigneeTakeda Pharmaceutical Company Limited
InventorsTaiji Asami, Ayumu Niida
Life of this patent
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Abstract
The present invention relates to a peptide compound that may be useful in the treatment or prophylaxis of obesity, diabetes and the like. More specifically, the present invention relates to a peptide compound represented by the formula (I): P1-Tyr-Aib-Glu-Gly-Thr-α-MePhe-Thr-Ser-Asp-Lys(-Gly-Gly-Gly-Gly-RA10)-A11-A12-Aib-Leu-A15-Lys-Gln-A18-Gln-Iva-Glu-Phe-Val-Arg-His-Leu-Leu-Asn-Lys-Aib-Thr-Arg-Gln-Arg-A35-NH2 wherein each symbol is as defined in the specification, and the treatment or prophylaxis of obesity, diabetes and the like using the peptide compound.
Claims15
A peptide represented by the formula (I):
- P1-Tyr-Aib-Glu-Gly-Thr-α-MePhe-Thr-Ser-Asp-Lys(-Gly-Gly-Gly-Gly-RA10)-A11-A12-Aib-Leu-A15-Lys-Gln-A18-Gln-Iva-Glu-Phe-Val-Arg-His-Leu-Leu-Asn-Lys-Aib-Thr-Arg-Gln-Arg-A35-NH2
- wherein
- P1 is a group represented by the formula:
- —RA1,
- —CO—RA1,
- —CO—ORA1,
- —CO—CORA1,
- —SO—RA1,
- —SO2—RA1,
- —SO2—ORA1,
- —CO—NRA2RA3,
- —SO2—NRA2RA3,
- or
- —C(═NRA1)—NRA2RA3
- wherein RA1, RA2 and RA3 are each independently a hydrogen atom, an optionally substituted hydrocarbon group, or an optionally substituted heterocyclic group;
- RA10 is Pal or Oda;
- A11 is Aib, Ala or Ser;
- A12 is Ile or Lys;
- A15 is Asp or Glu;
- A18 is Ala or Arg;
- and
- A35 is Tyr or Phe(2-F),
- or a salt thereof.
H-Tyr-Aib-Glu-Gly-Thr-αMePhe-Thr-Ser-Asp-Lys(-Gly-Gly-Gly-Gly-Pal)-Aib-Ile-Aib-Leu-Glu-Lys-Gln-Arg-Gln-Iva-Glu-Phe-Val-Arg-His-Leu-Leu-Asn-Lys-Aib-Thr-Arg-Gln-Arg-Tyr-NH2
- or a salt thereof.
H-Tyr-Aib-Glu-Gly-Thr-αMePhe-Thr-Ser-Asp-Lys(-Gly-Gly-Gly-Gly-Pal)-Ala-Ile-Aib-Leu-Glu-Lys-Gln-Arg-Gln-Iva-Glu-Phe-Val-Arg-His-Leu-Leu-Asn-Lys-Aib-Thr-Arg-Gln-Arg-Tyr-NH2
- or a salt thereof.
Me-Tyr-Aib-Glu-Gly-Thr-αMePhe-Thr-Ser-Asp-Lys(-Gly-Gly-Gly-Gly-Pal)-Ser-Ile-Aib-Leu-Glu-Lys-Gln-Arg-Gln-Iva-Glu-Phe-Val-Arg-His-Leu-Leu-Asn-Lys-Aib-Thr-Arg-Gln-Arg-Tyr-NH2
- or a salt thereof.
Dependencies are inferred from the claim text.