Polymer particles and uses thereof
OwnerBernd Helmut Adam Rehm, Bryce Malcolm Buddle +1inventors
InventorsBernd Helmut Adam Rehm, Bryce Malcolm Buddle, David Neil Wedlock
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Abstract
The present invention relates to polymer particles and uses thereof. In particular the present invention relates to functionalized polymer particles, processes of production and uses thereof in the diagnosis, treatment or prevention of tuberculosis.
Claims10
A method of diagnosing tuberculosis in a subject, the method comprising administering to the subject an effective amount of at least one polymer particle comprising one or more fusion polypeptides, wherein one or more of the fusion polypeptides comprise a particle-forming protein and three or more selected from the group consisting of:
- a. an ESAT6 antigen;
- b. a CFP10 antigen,
- c. an Rv3615c antigen,
- d. an Rv3020c antigen, and
- e. an Rv2346c antigen,
- and detecting an immune response in the subject, wherein the presence of an immune response is indicative of tuberculosis.
A method of detecting M. tuberculosis or M. bovis in a subject, the method comprising:
- providing a sample from a subject,
- contacting the sample with at least one polymer particle comprising one or more fusion polypeptides, wherein one or more of the fusion polypeptides comprise a particle-forming protein and three or more selected from the group consisting of:
- a. an ESAT6 antigen;
- b. a CFP10 antigen,
- c. an Rv3615c antigen,
- d. an Rv3020c antigen, and
- e. an Rv2346c antigen, and
- detecting a response indicative of exposure of the subject to one or more M. tuberculosis or M. bovis antigens,
- wherein the response is indicative of M. tuberculosis or M. bovis in the subject.
Dependencies are inferred from the claim text.