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US 10,501,499 B2Granted
Peptides derived from viral proteins for use as immunogens and dosage reactants
AssigneeBionor Immuno AS
InventorsBirger Sorensen, Mats Okvist, Arnt Ove Hovden, Maja Sommerfelt Gronvold
Life of this patent
Estimating the term…
Abstract
The present invention relates to novel peptides and methods for treatment, diagnosis and prognosis of virus infections including infections with HCV, HIV, HPV, CMV and Influenza. The invention further relates to methods for identifying and providing peptides useful for the treatment and diagnosis.
Claims9
An isolated monomeric peptide comprising the following structure
- Z1-Z2-Z3-Z4-Z6-Z7-Z9
- wherein Z1, Z4, and optional Z7 defines a linear sequence of one, two, or three arginine residues or derivatives thereof optionally followed by a glycine (G);
- Z2 defines an optional amino acid selected from 2,3-Diaminopropionic acid (Dpr), Cysteine, Lysine, Aspartic acid, and Glutamic acid, or a derivative thereof;
- Z3 selected from the group consisting of GGQLIGGIYLIPG (SEQ ID NO:313), VITYSIFLIVS (SEQ ID NO:314), TANWARVIS (SEQ ID NO:315), GYLPAVGAPI (SEQ ID NO:316), NIVP(Nle)VVTA (SEQ ID NO:317), VTPADLIGA (SEQ ID NO:318), PRPEGYTLFF (SEQ ID NO:319), LPYPRGYTLFV (SEQ ID NO:320), ETILTPRDV (SEQ ID NO:321), SSTSPVYDL (SEQ ID NO:322), TAYER(Nle)CNIL (SEQ ID NO:323), TVIGAS(Nle)IPLL (SEQ ID NO:324), AAFEE(Nle)(Har)ITS (SEQ ID NO:325), GLEPLVIAGILA (SEQ ID NO:326), TAFLVRNVA (SEQ ID NO:327), TPI(Har)QDWGNRAN (SEQ ID NO:328), TPT(Har)NGWDVKLS (SEQ ID NO:329), LECVYCKQQLL (SEQ ID NO:330), GVYDFAFRDLC (SEQ ID NO:331), GVFDYAFRDIN (SEQ ID NO:332), and VDIRTLEDLL (SEQ ID NO:333);
- wherein Z6 is selected from the group consisting of EVYDFAFRDLC (SEQ ID NO:334), GFAFRDLCIVY (SEQ ID NO:335), GFAYRDINLAY (SEQ ID NO:336), GTLGIVCPIG (SEQ ID NO:337), GLEPLVIAGILA (SEQ ID NO:338), TPI(Har)QDWENRAN (SEQ ID NO:339), VAFEDL(Har)(Nle)(Nle)SFI (SEQ ID NO:340), RFQTVVQBA (SEQ ID NO:341), GSLVGLLHIVL (SEQ ID NO:342), SIARSVTI(Nle)(Har)ASVVH (SEQ ID NO:343), TPTRQEWDCRIS (SEQ ID NO:344), TPTRQEWDARIS (SEQ ID NO:345), TPI(Har)QEW(Har)SL(Nle)NQEW (SEQ ID NO:346), IGDLIVAQV (SEQ ID NO:347), QYNPVAV(Nle)F (SEQ ID NO:348), GYTLFFTS (SEQ ID NO:349), GYTLFVSD (SEQ ID NO:350), NTL(Nle)TPRDV (SEQ ID NO:351), SSTSPVYNL (SEQ ID NO:352), VITFSIYLIVS (SEQ ID NO:353), GGNVIGGIY(Nle)IPR (SEQ ID NO:354), ANWAKVIL (SEQ ID NO:355), VIRVIAHGLRL (SEQ ID NO:356), and IGDLIVQAV (SEQ ID NO:478);
- and wherein optional Z9 is NWAKVI, wherein Nle is Norleucine and Har is homoarginine.
3 more elements
An isolated dimeric or multimeric peptide comprising two or more covalently joined monomeric peptides, each monomeric peptide independently comprising the following structure
- Z1-Z2-Z3-Z4-Z6-Z7-Z9
- wherein Z1, Z4, and optional Z7 defines a linear sequence of one, two, or three arginine residues or derivatives thereof optionally followed by a glycine (G);
- Z2 defines an optional amino acid selected from 2,3-Diaminopropionic acid (Dpr), Cysteine, Lysine, Aspartic acid and Glutamic acid, or a derivative thereof;
- wherein Z3 is selected from the group consisting of GGQLIGGIYLIPG (SEQ ID NO:313), VITYSIFLIVS (SEQ ID NO:314), TANWARVIS (SEQ ID NO:315), GYLPAVGAPI (SEQ ID NO:316), NIVP(Nle)VVTA (SEQ ID NO:317), VTPADLIGA (SEQ ID NO:318), PRPEGYTLFF (SEQ ID NO:319), LPYPRGYTLFV (SEQ ID NO:320), ETILTPRDV (SEQ ID NO:321), SSTSPVYDL (SEQ ID NO:322), TAYER(Nle)CNIL (SEQ ID NO:323), TVIGAS(Nle)IPLL (SEQ ID NO:324), AAFEE(Nle)(Har)ITS (SEQ ID NO:325), GLEPLVIAGILA (SEQ ID NO:326), TAFLVRNVA (SEQ ID NO:327), TPI(Har)QDWGNRAN (SEQ ID NO:328), TPT(Har)NGWDVKLS (SEQ ID NO:329), LECVYCKQQLL (SEQ ID NO:330), GVYDFAFRDLC (SEQ ID NO:331), GVFDYAFRDIN (SEQ ID NO:332), and VDIRTLEDLL (SEQ ID NO:333);
- wherein Z6 is selected from the group consisting of EVYDFAFRDLC (SEQ ID NO:334), GFAFRDLCIVY (SEQ ID NO:335), GFAYRDINLAY (SEQ ID NO:336), GTLGIVCPIG (SEQ ID NO:337), GLEPLVIAGILA (SEQ ID NO:338), TPI(Har)QDWENRAN (SEQ ID NO:339), VAFEDL(Har)(Nle)(NLE)SFI (SEQ ID NO:340), RFQTVVQBA (SEQ ID NO:341), GSLVGLLHIVL (SEQ ID NO:342), SIARSVTI(Nle)(Har)ASVVH (SEQ ID NO:343), TPTRQEWDCRIS (SEQ ID NO:344), TPTRQEWDARIS (SEQ ID NO:345), TPI(Har)QEW(Har)SL(Nle)NQEW (SEQ ID NO:346), IGDLIVAQV (SEQ ID NO:347), QYNPVAV(Nle)F (SEQ ID NO:348), GYTLFFTS (SEQ ID NO:349), GYTLFVSD (SEQ ID NO:350), NTL(Nle)TPRDV (SEQ ID NO:351), SSTSPVYNL (SEQ ID NO:352), VITFSIYLIVS (SEQ ID NO:353), GGNVIGGIY(Nle)IPR (SEQ ID NO:354), ANWAKVIL (SEQ ID NO:355), VIRVIAHGLRL (SEQ ID NO:356), and IGDLIVQAV (SEQ ID NO:478);
- and wherein optional Z9 is NWAKVI, wherein Nle is Norleucine and Har is homoarginine.
3 more elements
Dependencies are inferred from the claim text.