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US 10,501,497 B2Granted
Cyclic polypeptides, method for obtaining them and the therapeutic use thereof
AssigneeAxoltis Pharma
InventorsDominique Bridon, Stéphane Gobron
Life of this patent
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Abstract
The invention relates to a polypeptide #including the following amino acid sequence: W-S-X1-W-X2-X3-C-S-X4-C-G (SEQ ID NO: 59), wherein X1, X2 and X3 are, independently of one another, S or G, X4 is R-S or V-S or V-T or R-T, and both cysteines form a disulfide bridge.
Claims22
Polypeptide comprising the amino acid sequence SEQ ID NO:
- 59,
- wherein the two cysteines form a disulfide bridge;
- and
- wherein the polypeptide is substantially free of the reduced or dimeric or oligomeric forms of the polypeptide as well as derivatives of the polypeptide in which the thiol groups are in the sulfoxide or sulfone form.
1 more element
Method for obtaining the polypeptide of amino acid sequence SEQ ID NO:
- 59
- having the two cysteines form a disulfide bridge, from a starting polypeptide of sequence SEQ ID NO:
- 70,
- wherein the starting polypeptide of sequence SEQ ID NO:
- 70 is in solution;
- comprising forming a disulfide bridge in the presence of albumin in the starting polypeptide of sequence SEQ ID NO:
- 70.
4 more elements
Method for obtaining the polypeptide of amino acid sequence SEQ ID NO:
- 2
- from a starting polypeptide of sequence SEQ ID NO:
- 58:
- comprising forming a disulfide bridge in the presence of albumin in the starting polypeptide of sequence SEQ ID NO:
- 58.
2 more elements
Dependencies are inferred from the claim text.